HIV-1 Transmission Goes Retro (Steps Back)

Three steps forward, two steps back.

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Evolution steps back

Translocon: don't pass me by ranslocon proteins are intimately involved with the proteins they import into the ER—including transmembrane portions of the incoming proteins, based on results from Import of membrane proteins into the ER requires a joint effort between the T ribosome and the translocon to ensure that each domain of the translocating protein is targeted correctly to either the lume...

HIV/AIDS Disease: Transmission Transition

HIV-1 envelope glycan moieties modulate HIV-1 transmission.

UNLABELLED The HIV-1 envelope protein (Env) is heavily glycosylated, with approximately 50% of the Env molecular mass being contributed by N-glycans. HIV-1 Env N-glycans shield the protein backbone and have been shown to play key roles in determining Env structure, surface exposure, and, consequently, antigenicity, infectivity, antibody neutralization, and carbohydrate and receptor binding. Stu...

Mother-to-infant transmission of HIV-1: the placenta fights back.